GHRH

RESEARCH PEPTIDES · GLOSSARY ENTRY

GHRH (Growth Hormone Releasing Hormone)

A hypothalamic peptide that stimulates pituitary release of growth hormone — the endogenous trigger that synthetic GHRH analogues mimic.

Why it matters

GHRH is a 44-amino-acid peptide produced in the hypothalamus. It binds GHRH receptors on pituitary somatotrophs, triggering growth hormone release. Synthetic GHRH analogues (sermorelin, tesamorelin, CJC-1295) are designed to extend the half-life and effective dose of the natural signal.

In practice

For research peptide consumers, GHRH analogues are the upstream class — they prompt the pituitary to release GH rather than supplying exogenous GH. The GH released is therefore pulsatile and physiological in character.

Common confusion

GHRH analogues and direct GH (somatropin) are not equivalent — pulsatile GH release through GHRH stimulation differs from sustained exogenous GH administration.

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    This glossary entry is editorial content reviewed against primary sources. It is not medical advice. See our Editorial Policy.

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