Retatrutide

Glossary / Research Peptides / Retatrutide
RESEARCH PEPTIDES · GLOSSARY ENTRY

Retatrutide

An investigational triple agonist at GLP-1, GIP, and glucagon receptors — Eli Lilly’s next-generation obesity drug, currently in Phase 3 trials.

Why it matters

Retatrutide adds glucagon agonism to the dual GLP-1/GIP profile of tirzepatide. Phase 2 data showed weight loss of about 24% over 48 weeks at the highest tested dose — substantially larger than tirzepatide or semaglutide. The glucagon component is hypothesised to add metabolic rate and fat oxidation effects on top of the appetite suppression.

In practice

Phase 3 trials are underway. If approved, retatrutide would be the most powerful weight-loss medication on the market. The research peptide market has already begun offering retatrutide for research use.

Common confusion

Research-market retatrutide is not the same as a finished pharmaceutical product — purity, dose accuracy, and sterility are the buyer’s responsibility.

SOURCES

    This glossary entry is editorial content reviewed against primary sources. It is not medical advice. See our Editorial Policy.

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