Why it matters
Anandamide (Sanskrit ananda = “bliss”) was the first endocannabinoid identified. It is produced on demand from membrane phospholipids and rapidly hydrolysed by fatty acid amide hydrolase (FAAH). Functions include pain modulation, mood regulation, appetite, and the “runner’s high” associated with sustained aerobic exercise.
In practice
Pharmacologically, FAAH inhibitors that raise endogenous anandamide are an active drug-development class. Acetaminophen indirectly raises anandamide via a metabolite; some of its analgesic effect may be cannabinoid-mediated.
Common confusion
Anandamide is not equivalent to THC — its effects are subtler because the body degrades it rapidly. THC stays in the system long enough to produce sustained CB1 activation.
This glossary entry is editorial content reviewed against primary sources. It is not medical advice. See our Editorial Policy.